Toxicology

Please click on the toxicology references below to read the entire article. Check back occasionally as new toxicology articles will be posted.

2008

• Fine-Tuning Compound Safety Assessments
  ( GEN Vol. 28, No. 6 )
• Characteristics of Genomic Signatures Derived Using Univariate Methods and Mechanistically Anchored Functional Descriptors for Predicting Drug- and Xenobiotic-Induced Nephrotoxicity
  ( Toxicology Mechanisms and Methods, Volume 18, Issue 2 & 3, pages 267 - 276 )
• Combined Computational Metabolite Prediction and Automated Structure-Based Analysis of Mass Spectrometric Data
  ( Toxicology Mechanisms and Methods, Volume 18, Issue 2 & 3, pages 243 - 250 )

2007

• Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite
  ( Toxicology and Applied Pharmacology Volume 227, Issue 3, 15 March 2008, Pages 400-416 )
• Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicide
  ( Toxicology and Applied Pharmacology Volume 227, Issue 3, 15 March 2008, Pages 357-369 )
• Affymetrix and Illumina, a toxicogenomic based interplatform interplatform comparison
  ( Molecular Toxicology, Institute of Toxicology, Merck Serono Research, 64271 Darmstadt, Germany )
• Acute Hepatotoxicity: A Predictive Model Based on Focused Illumina Microarrays
  ( Toxicological Sciences 99(1), 289-302 (2007) )
• Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening.
  ( Toxicol. Appl. Pharmacol. (2007), doi:10.1016/j.taap.2007.08.026 )
• Toxicogenomics in the assessment of immunotoxicity
  ( Methods 41, 132-141, 2007 )
• In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics
  ( Toxicology 2007, accepted )
• Estrogenic Effects in the Immature Rat Uterus after Dietary Exposure to Ethinylestradiol and Zearalenone Using a Systems Biology Approach
  ( Toxicological Sciences 99(1), 303-314 (2007) )

2006

• Gene Expression Profiling of Bis(tri-n-butyltin)oxide (TBTO)-Induced Immunotoxicity in Mice and Rats
  ( Journal of Immunotoxicology, 3:227-244, 2006 )
• Chronic quercetin exposure affects fatty acid catabolism in rat lung
  ( Cell. Mol. Life Sci. 63 (2006) 2847 - 2858. December 2006 )
• Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms
  ( Xenobiotica, Volume 36, Issue 10 & 11 October 2006 , pages 877 - 901 )
• Evaluation of immunomodulation by Lactobacillus casei Shirota: immune function, autoimmunity and gene expression
  ( International Journal of Food Microbiology 112, 8-18, 2006 )

2005

• Systems level analysis of drug metabolism and its effects in human biology
  ( Bioinformatics. 2005, submitted )
• A Combined Approach to Drug Metabolism and Toxicity Assessment
  ( Drug Metabolism and Disposition 34:495-503, 2006 )
• Reengineering the pharmaceutical industry by crash-testing molecules
  ( Drug Disc Today, Vol.10 Num. 17, September 2005 )
• Computational prediction of Human Drug Metabolism
  ( xpert Opinion. Drug Metab. Toxicol. (2005) )
• Use of the local lymph node assay in assessment of immune function
  ( Toxicology 211, 107-114, 2005 )
• A Novel Method for Generation of Signature Networks as Biomarkers from Complex High Throughput Data
  ( Tox. Letters 158: 20-29, 2005 )
• Application of systems biology to absorption, distribution, metabolism, excretion and toxicity
  ( Trends in Pharmacological Sciences, Vol.26, No.4, 202-209, April 2005 )
• A Novel Method for Visualizing Nuclear Hormone Receptor Networks Relevant to Drug Metabolism
  ( Drug Metabolism and Disposition, Vol.33, No.3 2005 )

2004

• Quantitative Structure-metabolism Relationship Modeling of Metabolic N-dealkylation Reaction Rates
  ( Drug Metabolism and Disposition, DMD 32:1111-1120, 2004 )
• Kohonen Maps for Prediction of Binding to Human Cytochrome P450 3A4
  ( Drug Metabolism and Disposition, DMD 32:1183-1189, 2004 )
• Early Prediction of Drug Metabolism and Toxicity: Systems Biology Approach and Modeling
  ( Drug Discovery Today, DDT Vol.9, No.3, February 2004 )

2003

• Modeling of Human Cytochrome P450-Mediated Drug Metabolism Using Unsupervised Machine Learning Approach
  ( Journal of Medicinal Chemistry, 46: 3631-3643, 2003 )