MetaCore/MetaDrug (MC/MD bundle) Discovery Platform™ - Systems Biology & Pathway Analysis
This integrated informatics platform represents our most comprehensive off-the-shelf offering, which includes the complete MetaCore™ platform for pathway analysis seamlessly integrated with MetaDrug™. GeneGo customers will find this systems biology solution ideal for preclinical and clinical stage drug discovery, as it offers a powerful solution for analyzing data generated by high-throughput biology and chemistry experiments. The MC/MD bundle imports virtually any type of experimental OMICs data, high-content screening (HCS) assay data, compound structures, SMILES strings, CAS numbers and brutto formulas and custom interactions. It enables integration, visualization and analysis of these diverse data sets simultaneously, on the same backbone of biological pathways and networks. The MC/MD Discovery Platform targets large, integrated drug discovery programs managing multiple types of biological and chemistry data accumulated throughout the discovery pipeline from hits to lead series, drug candidates and eventually, marketed drugs. GeneGo offers the MC/MD bundle as an enterprise solution. We also provide web access for discovery, screening and regulatory organizations.
Product highlights
- Analyze ANY experimental high-throughput data in the context of pathways, networks and maps
- Identify affected pathways and networks for your lists of genes, proteins, transcripts or compounds affected in a disease or as a result of drug action
- Easy-to-use workflow wizards for data upload, analysis and interpretation
- Evaluate potential indications, off-target effects, mechanism of action and toxicity starting from structures
- Parses individual and batch structures in MOL or SD files
- Substructure and similarity search through bioactive chemistry space in GeneGo databases
- Most relevant cellular processes, toxic categories, diseases and conditions
- Manually curated networks for diseases, toxic categories and cellular processes
- Signature networks for drug response and disease condition
- Intuitive pathway analysis editing and visualization tools
- Multiple network generating algorithms
- Seamless integration with Elsevier MDL’s DiscoveryGate family of databases
- Concurrently visualize and cross-validate different types of data
- Take advantage of the annotated content database that took over 100 man-years to assemble
- Visualize mouse, rat, worm, fly, yeast data on maps and networks
- Mine your data in real time: multiple data points, conditions, time-series, treatments through animated videos
- Apply disease, tissue, functional processes and sub-cellular localization filters to focus networks on information relevant to study
- Select, save & export high resolution images of pathways and networks for pathway analysis applications
Data analysis tools
- Multiple ways to generate networks
- 10 network-generating algorithms
- Specificity filters for tissues, functional processes, sub-cellular localization, interaction mechanisms, species etc.
- Enrichment analysis in multiple ontology’s: GeneGo annotated processes, canonical pathways, GO processes and human diseases
- Statistical tests and scoring for network relevance to the dataset, functional processes, cellular pathways and transcription factors
- Multiple types of P-value calculations for enrichment analysis and network prioritization
- Multiple logical operations on networks and gene lists
- Over 2 million resolved synonyms for genes, proteins and compounds
- Custom network edititing
- Query for genes, proteins, compounds, reactions, pathways, drugs and diseases
- Parsers for microarray gene expression, proteomics, siRNA screens, metabolomics and other high-throughput data
- Prioritization in multiple functional categories: diseases, toxicity, cellular processes and canonical pathway maps
- Enables concurrent visualization of multiple data types for robust pathway analysis applications
- One-button comparison of toxicogenomics and drug effect gene expression profiles
- Reporting in Excel
Content
- Unique manually curated database on xenobiotics effects
- Tens of thousands of human xenobiotic reactions
- All marketed drugs with targets and downstream signaling
- Compounds and biologicals in clinical trials, with targets
- Kinetic data for many important enzymes of drug metabolism
- Comprehensive coverage of ligand-receptor interactions from peer-review literature and patents
- Licensing models that enable users to add their own proprietary data
- Unique pathway maps for diseases, toxicities and drug effect
System design
- Unique, Oracle-based database architecture
- Compatibility with pharmaceutical IT infrastructure
- Seamlessly integrated with editing tools MapEditor™ for pathway analysis and MetaLink™
- Server-client architecture
- Oracle database architecture
- Seamless compatibility with customer’s IT infrastructure
- Web-based access or “behind-the-firewall” internal server installation
- Named user or concurrent licenses